منابع مشابه
Dissecting hematopoiesis and disease using the zebrafish.
The study of blood has often defined paradigms that are relevant to the biology of other vertebrate organ systems. As examples, stem cell physiology and the structure of the membrane cytoskeleton were first described in hematopoietic cells. Much of the reason for these successes resides in the ease with which blood cells can be isolated and manipulated in vitro. The cell biology of hematopoiesi...
متن کاملDissection of vertebrate hematopoiesis using zebrafish thrombopoietin.
In nonmammalian vertebrates, the functional units of hemostasis are thrombocytes. Thrombocytes are thought to arise from bipotent thrombocytic/erythroid progenitors (TEPs). TEPs have been experimentally demonstrated in avian models of hematopoiesis, and mammals possess functional equivalents known as megakaryocyte/erythroid progenitors (MEPs). However, the presence of TEPs in teleosts has only ...
متن کاملHEMATOPOIESIS AND STEM CELLS Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin
Department of Cell Differentiation, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic v.v.i., Prague, Czech Republic; Department of Cellular and Molecular Medicine, and Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA; and Stem Cell Program and Division of Hematology/Oncology, Children’s Hospital and Dana-Farber Cancer Institu...
متن کاملMiR-145 regulates hematopoiesis during zebrafish development
MicroRNA-145 (miR-145) is considered to play key role in many cellular processes, such as proliferation, differentiation and apoptosis by inhibiting target gene expression. The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression. We are beginning to understand the functions of miRNA-145 played during essential biological processes ...
متن کاملThe role of stat1b in zebrafish hematopoiesis
STAT1 mediates response to interferons and regulates immunity, cell proliferation, apoptosis, and sensitivity of Fanconi Anemia cells to apoptosis after interferon signaling; the roles of STAT1 in embryos, however, are not understood. To explore embryonic functions of STAT1, we investigated stat1b, an unstudied zebrafish co-ortholog of human STAT1. Zebrafish stat1a encodes all five domains of t...
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ژورنال
عنوان ژورنال: Blood Cells, Molecules, and Diseases
سال: 2013
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2013.07.009